RP-HPLC method for simultaneous estimation of atorvastatin calcium and ramipril from plasma
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Simultaneous RP-HPLC estimation and validation of ramipril and atorvastatin in bulk and combined tablet formulation
A simple, precise, accurate and reproducible RP-HPLC method was developed and validated for simultaneous estimation of ramipril and atorvastatin in bulk and combined pharmaceutical formulations. Separation of ramipril and atorvastatin was successfully achieved on an Inertsil ODS C18 column (150mm x 4.6mm x 5 μm). The mobile phase consisted of 0.1% ortho phosphoric acid and methanol (60:40, v/v)...
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Volume 1(2) March-April 2013 Page 244 SIMULTANEOUS ESTIMATION OF OLMESARTAN AND ATORVASTATIN IN BULK AND FROMULATION BY USING UV SPECTROSCOPY AND RP-HPLC Revanth Reddy B * , Aravind G Nimra college of pharmacy, Vijayawada *Corresponding author: E.mail: [email protected] ABSTRACT Simple, rapid and accurate UV Spectroscopic (Simultaneous Equation method and First order derivative method) a...
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A rapid, sensitive and specific RP-HPLC method involving UV detection was developed and validated for determination and quantification of Atorvastatin and Ramipril. Chromatography was carried out on a Phenomenex – Luna, C18 (250 x 4.6 mm i.d.,5μ) column. using filtered and degassed mixture of acetonitrile ,water and methanol (55:40:5) as mobile phase at a flow rate of 1.0 ml/min and effluent wa...
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A reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of atorvastatin calcium and fenofibrate in tablet formulation. The separation was achieved by Luna C18 column and methanol:acetate buffer pH 3.7 (82:18 v/v) as mobile phase, at a flow rate of 1.5 ml/min. Detection was carried out at 248 nm. Retention time of atorvastatin calcium and feno...
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The present study describes a simple, accurate, precise and cost effective UV-Vis Spectroscopic and RP-HPLC method for the estimation of Ibandronate sodium (IBN). The determination of Ibandronate sodium (IBN) was performed by both UV and RP-HPLC method using 215 nm as the determination wavelength. The drug was dissolved in NaOH solution (0.1N NaOH) for estimation in UV and in distilled water fo...
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تاریخ انتشار 2011